The following acne drugs should not be used use during pregnancy:
Topical retinoids
These consist of tretinoin, Retin-A, Differin, Tazorac, and Avita. Even though there is minimal absorption of topical retinoids that can potentially reach a fetus, and there's no evidence that these agents can harm an unborn child, you should stop applying them once you think that you're pregnant. Clindamycin: Prescription product s that contain this antibiotic include Cleocin-T, as well as several generics. The effects of clindamycin during pregnancy haven't been adequately studied. Clindamycin combined with Benzoyl peroxide is also found in the combination products Benzaclin Gel and DuacGel. Because clindamycin may appear in breast milk and could affect a nursing infant, it's probably not advisable to use products containing it if you are pregnant or plan to become pregnant.
Aczone Gel
This agent contains dapsone. There is minimal absorption of this drug in the bloodstream when it's applied topically; however, it's known that dapsone is excreted inhuman milk when taken orally.
Clindamycin and Benzoyl peroxide are also found in the combination products Benzaclin Gel and Duac Gel.
I recommend avoiding all oral medicines to treat acne when you're pregnant. However, an oral penicillin derivative, such as Amoxicillin (if you're not allergic to it), may be taken safely if your acne is really bad. If you're allergic to penicillin or it's not working, your dermatologist may prescribe another oral antibiotic that can be used in pregnancy.
Many oral drugs can harm your unborn baby. In these cases, clear evidence exists that your child may have serious birth defects if you use them. The following medications must be avoided if you're pregnant or if you're contemplating becoming pregnant:
Tetracycline
Tetracycline and its derivatives, minocycline and Doxycycline, may cause some inhibition of bone growth and discoloration of teeth in a fetus.
Hormones
The anti-androgens such as spironolactone that are sometimes used to treat acne, can, by blocking testosterone, interfere with the normal development of a male fetus and cause feminization. (See Chapter 11.)
Oral isotretinoin (Accutane)
Oral isotretinoin (eye-so-tret-ih- no-in) available as Accutane, RoAccutane, Amnesteem, Claravis, and Sotret, is a powerful drug that's used to treat severe nodular acne in carefully selected patients. This drug can cause severe fetal abnormalities. There are many restrictions currently in place regarding oral isotretinoin, and with understandable cause. Oral isotretinoin can cause serious birth defects to infants born to women exposed to them. They should never - not under any circumstances - be taken during pregnancy! Even if a woman becomes pregnant within one month after stopping the drug, problems can still occur. There also is an increased risk of miscarriage, premature births, and infant death associated with taking oral isotretinoin during pregnancy.
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